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Ivermectin is an antiparasitic drug. [7] After its discovery in 1975, [8] its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. [9] Approved for human use in 1987, [10] it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis.
Escitalopram is the (S)- enantiomer of citalopram (which exists as a racemate), hence the name es -citalopram. [ 9 ] Escitalopram was approved for medical use in the United States in 2002. [ 9 ] Escitalopram is rarely replaced by twice the dose of citalopram; escitalopram is safer and more effective. [ 11 ]
Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon; [9] [21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9]
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Bupropion was originally called by the generic name amfebutamone, before being renamed in 2000. [ 16 ] In 2022, it was the 21st most commonly prescribed medication in the United States, with more than 25 million prescriptions. [ 38 ][ 39 ] It is on the World Health Organization's List of Essential Medicines.
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