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As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor. As a first-generation antihistamine, it typically crosses the blood–brain barrier into the brain, thereby producing a suite of sedative and hypnotic effects that are mediated by the central nervous system. (N.b.:
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Its use is not recommended in young children or the elderly. [11] [12] There is no clear risk of harm when used during pregnancy; however, use during breastfeeding is not recommended. [13] It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
Frequency. ~75% of pregnancies [ 4][ 5] Morning sickness, also called nausea and vomiting of pregnancy ( NVP ), is a symptom of pregnancy that involves nausea or vomiting. [ 1] Despite the name, nausea or vomiting can occur at any time during the day. [ 2] Typically the symptoms occur between the 4th and 16th week of pregnancy. [ 2]
Treatment involves elevation of the legs and pressure stockings to relieve swelling along with warm sitz baths to decrease pain. There is a small amount of evidence that rutosides (a herbal remedy) may relieve symptoms of varicose veins in late pregnancy but it is not yet known if rutosides are safe to take in pregnancy.
Hypothyroidism is common in pregnancy with an estimated prevalence of 2-3% and 0.3-0.5% for subclinical and overt hypothyroidism respectively. [8] Endemic iodine deficiency accounts for most hypothyroidism in pregnant women worldwide while chronic autoimmune thyroiditis is the most common cause of hypothyroidism in iodine sufficient parts of the world.
Gestational diabetes is a condition in which a person without diabetes develops high blood sugar levels during pregnancy. [ 2] Gestational diabetes generally results in few symptoms; [ 2] however, it increases the risk of pre-eclampsia, depression, and of needing a Caesarean section. [ 2] Babies born to individuals with poorly treated ...
Itopride ( INN; brand name Ganaton) is a prokinetic benzamide derivative. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. [ 3] Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. [ 4] It is a combined D 2 receptor antagonist and ...
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