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Moxifloxacin is an antibiotic, used to treat bacterial infections, [ 4 ] including pneumonia, conjunctivitis, endocarditis, tuberculosis, and sinusitis. [ 4 ][ 5 ] It can be given by mouth, by injection into a vein, and as an eye drop. [ 5 ] Common side effects include diarrhea, dizziness, and headache. [ 4 ]
Gatifloxacin. Gatifloxacin (brand names Gatiflo, Tequin, and Zymar) is an antibiotic of the fourth-generation fluoroquinolone family, [1] that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV. It was patented in 1986 and approved for medical use in 1999. [2]
It can be taken by mouth, as eye drops, as ear drops, or intravenously. [5] [6] Common side effects include nausea, vomiting, and diarrhea. [5] Severe side effects include an increased risk of tendon rupture, hallucinations, and nerve damage. [5] In people with myasthenia gravis, there is worsening muscle weakness. [5]
It is particularly used for infections of the skin, respiratory system and mammary glands in dogs and cats, as well as with urinary tract infections. For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection. [4]
Ripasudil's mechanism of action affects intraocular pressure, or IOP, "by directly acting on the trabecular meshwork, thereby increasing conventional outflow through the Schlemm’s canal." [2] More simply, it is an "out-flow" drug that reduces IOP by stimulating the movement of aqueous humour from the ciliary body away from the eye. [3]
Tropicamide, sold under the brand name Mydriacyl among others, is a medication used to dilate the pupil and help with examination of the eye. [3] Specifically it is used to help examine the back of the eye. [4] It is applied as eye drops. [3] Effects occur within 40 minutes and last for up to a day.