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Metformin can induce modest but clinically significant weight loss in adults with obesity and without type 2 diabetes, according to evidence from randomized trials and real-world studies. Metformin may also prevent or delay diabetes and have favorable non-glycemic effects.
Design and patients: We treated 154 consecutive patients with a body mass index ≥27 kg/m(2) in an outpatient setting over 6 months with metformin up to a dosage of 2,500 mg per day. Additionally, we included 45 untreated patients as controls.
Listen to a podcast discussion on the evidence that supports metformin therapy for weight loss in adults with obesity and without type 2 diabetes. Learn about the benefits, risks, and dosage of metformin from experts at Cleveland Clinic.
Metformin is a diabetes drug that may also help with weight loss, but it's not a magic pill. Learn how metformin works, its dosage, side effects, effectiveness and alternatives for weight...
Metformin dosage for weight loss in non-diabetes. Metformin isn't approved as a weight loss medication, so there's no labeling information about what dose you should...
This study evaluated the efficacy of metformin for weight loss in overweight and obese people without diabetes through a network meta-analysis of 34 trials. It identified the most suitable dosage and intervention period for adolescents and adults, and found that metformin significantly decreased BMI and weight.
The FDA have not approved metformin for weight loss purposes. However, some doctors will prescribe it to people who are overweight or obese and have type 2 diabetes or prediabetes.
Can People Without Diabetes Take Metformin for Weight Loss? Some doctors are prescribing metformin off-label to people with prediabetes to help them avoid developing diabetes. Physicians may also prescribe metformin to non-diabetic individuals to help treat obesity and weight gain from taking antipsychotic medications ( 18 ).
A study of 154 obese patients treated with metformin for 6 months showed significant weight reduction compared to untreated controls. Metformin effectiveness depended on insulin resistance and was independent of age, sex or BMI.
A study of 154 obese patients treated with metformin for 6 months showed significant weight reduction compared to 45 untreated controls. Metformin was more effective in insulin resistant patients and independent of age, sex or BMI.