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It is thought to activate these receptors in the suprachiasmatic nucleus of the hypothalamus in the brain to regulate the circadian clock and sleep–wake cycles. [21] Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10] Prolonged-release melatonin used as a medication has a half-life of 3.5 to ...
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Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
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Adventures of the Gummi Bears is an American animated children's television series created by Jymn Magon and produced by Walt Disney Television Animation. [1] The series, loosely inspired by gummy bear candies, [2] takes place in a fantasy world of medieval lands and magic, and focuses on the lives of seven mystical beings known as Gummi Bears.
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