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Paroxysmal nocturnal hemoglobinuria ( PNH) is a rare, acquired, [1] life-threatening disease of the blood characterized by destruction of red blood cells by the complement system, a part of the body's innate immune system. This destructive process occurs due to deficiency of the red blood cell surface protein DAF, which normally inhibits such ...
Paroxysmal cold hemoglobinuria. Paroxysmal cold hemoglobinuria ( PCH) or Donath–Landsteiner hemolytic anemia ( DLHA) is an autoimmune hemolytic anemia featured by complement -mediated intravascular hemolysis after cold exposure. [1] It can present as an acute non-recurrent postinfectious event in children, or chronic relapsing episodes in ...
Hemoglobinuria. Hemoglobinuria is a condition in which the oxygen transport protein hemoglobin is found in abnormally high concentrations in the urine. [1] The condition is caused by excessive intravascular hemolysis, in which large numbers of red blood cells (RBCs) are destroyed, thereby releasing free hemoglobin into the plasma. [2]
Paroxysmal nocturnal dyspnea or paroxysmal nocturnal dyspnoea ( PND) is an attack of severe shortness of breath and coughing that generally occurs at night. [1] It usually awakens the person from sleep, and may be quite frightening. [2] PND, as well as simple orthopnea, may be relieved by sitting upright at the side of the bed with legs ...
Common symptoms include extreme fatigue, joint pain or skin rashes. In rare cases, the disease may lead to kidney or heart damage, or weaken the immune system so the body can’t fight off infections.
Paroxysmal attack. Paroxysmal attacks or paroxysms (from Greek παροξυσμός) are a sudden recurrence or intensification of symptoms, such as a spasm or seizure. [1] These short, frequent symptoms can be observed in various clinical conditions. They are usually associated with multiple sclerosis or pertussis, but they may also be ...
Paroxysmal sympathetic hyperactivity ( PSH) is a syndrome that causes episodes of increased activity of the sympathetic nervous system. Hyperactivity of the sympathetic nervous system can manifest as increased heart rate, increased respiration, increased blood pressure, diaphoresis, and hyperthermia. [1] Previously, this syndrome has been ...
2.3 per 1000 people [5] Paroxysmal supraventricular tachycardia ( PSVT) is a type of supraventricular tachycardia, named for its intermittent episodes of abrupt onset and termination. [3] [6] Often people have no symptoms. [1] Otherwise symptoms may include palpitations, feeling lightheaded, sweating, shortness of breath, and chest pain.