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The good news is that vaccines, which have been updated each year since 2022, are still expected to be effective at preventing severe disease, hospitalization, and death from COVID. In the U.S., infants, children, and adults ages 6 months and older are eligible to be vaccinated, according to the Centers for Disease Control and Prevention (CDC).
This report updates vaccine effectiveness (VE) estimates including all COVID-19 vaccines available through August 14, 2021, and examines whether VE differs for adults with increasing time since completion of all recommended vaccine doses.
The global efficacy of Ad26.COV2.S was lower, at 66% for the one-shot vaccine and 75% for the two-shot vaccine, as a result of the beta, lambda, and mu variants in Africa and South America.
Helps protect people of all ages against COVID-19 illness that is severe, requires hospital care, or causes death. Age 6 months to 4 years, unvaccinated: 3 doses. Age 6 months to 4 years, unvaccinated, weakened immune system: 3 doses. Age 6 months to 4 years, vaccinated previously: 1 or 2 doses.
BNT162b2, mRNA-1273 and Sputnik V after two doses had the highest efficacy (>90%) in preventing symptomatic cases in phase III trials. mRNA vaccines, AZD1222, and CoronaVac were effective in preventing symptomatic COVID-19 and severe infections against Alpha, Beta, Gamma or Delta variants.
Ranking by reported efficacy gives relative risk reductions of 95% for the Pfizer–BioNTech, 94% for the Moderna–NIH, 91% for the Gamaleya, 67% for the J&J, and 67% for the AstraZeneca–Oxford vaccines.
Vaccine effectiveness is a measure of how well vaccination protects people against health outcomes such as infection, symptomatic illness, hospitalization, and death. Vaccine effectiveness is generally measured by comparing the frequency of health outcomes in vaccinated and unvaccinated people.
Vaccine effectiveness after a ChAdOx1 nCoV-19 primary course increased to 70.1% (95% CI, 69.5 to 70.7) at 2 to 4 weeks after an mRNA-1273 booster and decreased to 60.9% (95% CI, 59.7 to 62.1)...
The vaccine’s effectiveness against the Omicron variant was 65.5% from 2 to 4 weeks, dropping to 8.8% at ≥25 weeks after two Pfizer doses. The booster increased the vaccine’s effectiveness to 73.9% from 2 to 4 weeks, then declined to 64.4% from 5 to 9 weeks [60].
Four studies assessed the efficacy and effectiveness of COVID-19 vaccines within 14 days of the 1st dose. In total, 3909 of 637,142 vaccinated subjects developed SARS-CoV-2 infection (symptomatic or asymptomatic) within 2 weeks after the 1st dose, compared to 5087 of 614,989 unvaccinated subjects.