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Rivastigmine (sold under the trade name Exelon among others) is a cholinesterase inhibitor used for the treatment of mild to moderate Alzheimer's disease. [4] The drug can be administered orally or via a transdermal patch; the latter form reduces the prevalence of side effects, [5] which typically include nausea and vomiting.
Plecanatide is a 16 amino acid peptide with the amino acid sequence: (one-letter sequence: NDECELCVNVACTGCL). Plecanatide is nearly structurally identical to human uroguanylin, apart from the substitution of Asp 3 with Glu 3. [ 13] Disulfide bonds exist between Cys 4 and Cys 12, as well as Cys 7 and Cys 15.
The most frequent side effects include headache, insomnia (difficulty sleeping), sleepiness, parkinsonism (effects similar to Parkinson's disease such as shaking, muscle stiffness and slow movement), dystonia (involuntary muscle contractions), tremor (shaking), dizziness, akathisia (restlessness), agitation, anxiety, depression, increased weight, nausea, vomiting, constipation, dyspepsia ...
Frederick (d. July 1002 or 15 March 1003), Count in the Harzgau and in the Nordthüringgau, was Count Palatine of Saxony from 995 to 996; Burchard I (d. after 3 November 1017), the first count of Goseck to hold the title, was a count in the Hassegau from 991, Count Palatine of Saxony from 1003, Count of Merseburg from 1004, and imperial ...
This is a list of palatines of Hungary.A palatine (Hungarian: nádorispán or nádor; also: Croatian: ugarski palatin; German: Palatin; Slovak: nádvorný župan or nádvorný špán, later: palatín or nádvorník) was the highest-ranking dignitary in the Kingdom of Hungary after the King of Hungary from the kingdom's rise in the 11th century up to 1848–1918.
Rupatadine is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H 1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies.
Dopamine D 2 and D 3 receptor occupancy in humans has been summarized as, "In healthy volunteers, single-dose cariprazine of 0.5 mg occupied up to 12% of striatal D 2 /D 3 receptors, while striatal D 2 /D 3 occupancy after multiple dosing up to cariprazine 1.0 mg/d ranged from 63 to 79% [39]. In an open-label, fixed-dose, 2-week trial in eight ...
Brotizolam is a highly potent and short-acting hypnotic, with a typical dose ranging from 0.125 to 0.25 milligrams, which is rapidly eliminated with an average half-life of 4.4 hours (range 3.6–7.9 hours). [ 8] It was patented in 1974 [ 9] and came into medical use in 1984. [ 10] Brotizolam is not approved for sale in the UK, United States or ...