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Similarly, dysfunctional SRF, which normally tethers Elk1 to the SRE, leads to Fos not being transcribed. [21] At the same time, without Elk1, SRF cannot induce c-fos transcription after MAPK stimulation. [16] For these reasons, Elk1 represents an essential link between signal transduction pathways and the initiation of gene transcription.
ELK1 and SAP1a have been shown to form ternary complexes with SRF on the serum response elements (SRE) located in the c-fos promoter. ELK1, SAPla, FLI1 and EWS-FLI1 are able to form ternary complexes with SRF on EGR1 SREs. In addition, ELK1 and SAP1a can also form quaternary complexes on the Egr1 SREI. Clinical significance
An epicanthic fold or epicanthus[ 6] is a skin fold of the upper eyelid that covers the inner corner (medial canthus) of the eye. [ 3] However, variation occurs in the nature of this feature and the possession of "partial epicanthic folds" or "slight epicanthic folds" is noted in the relevant literature. [ 7][ 8][ 9] Various factors influence ...
1:30,000 to 1:50,000. Leber's hereditary optic neuropathy ( LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predominantly affects young adult males. LHON is transmitted only through the mother ...
In molecular biology, extracellular signal-regulated kinases ( ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors ...
Sharon Stone is sparking concern among fans after sporting a black eye in a new photo shared via Instagram.. The Basic Instinct actress, who has been documenting her recent travels to Turkey and ...
A distant object is defined as an object located beyond 6 meters (20 feet) from the eye. When an object is located close to the eye, the rays of light from this object no longer approach the eye parallel to each other. Consequently, the eye must increase its refractive power to bring those rays of light together on the retina.
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