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Similarly, dysfunctional SRF, which normally tethers Elk1 to the SRE, leads to Fos not being transcribed. [21] At the same time, without Elk1, SRF cannot induce c-fos transcription after MAPK stimulation. [16] For these reasons, Elk1 represents an essential link between signal transduction pathways and the initiation of gene transcription.
ELK1 and SAP1a have been shown to form ternary complexes with SRF on the serum response elements (SRE) located in the c-fos promoter. ELK1, SAPla, FLI1 and EWS-FLI1 are able to form ternary complexes with SRF on EGR1 SREs. In addition, ELK1 and SAP1a can also form quaternary complexes on the Egr1 SREI. Clinical significance
An SRF technology single-cell Niobium cavity CAD image with cross section, as used in the KEK-B [1] accelerator. Superconducting radio frequency (SRF) science and technology involves the application of electrical superconductors to radio frequency devices. The ultra-low electrical resistivity of a superconducting material allows an RF resonator ...
20807 Ensembl ENSG00000112658 ENSMUSG00000015605 UniProt P11831 Q9JM73 RefSeq (mRNA) NM_003131 NM_001292001 NM_020493 RefSeq (protein) NP_001278930 NP_003122 NP_003122.1 NP_065239 Location (UCSC) Chr 6: 43.17 – 43.18 Mb Chr 17: 46.86 – 46.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serum response factor, also known as SRF, is a transcription factor protein. Function Serum ...
Plackett–Burman design. Plackett–Burman designs are experimental designs presented in 1946 by Robin L. Plackett and J. P. Burman while working in the British Ministry of Supply. [ 1] Their goal was to find experimental designs for investigating the dependence of some measured quantity on a number of independent variables (factors), each ...
Kruppel-like factors. In molecular genetics, the Krüppel-like family of transcription factors ( KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family. [1]
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In molecular biology, extracellular signal-regulated kinases ( ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors ...