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ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. [ 5] Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family, which is characterized by a common protein domain that regulates DNA binding to target sequences.
ELK1 and SAP1a have been shown to form ternary complexes with SRF on the serum response elements (SRE) located in the c-fos promoter. ELK1, SAPla, FLI1 and EWS-FLI1 are able to form ternary complexes with SRF on EGR1 SREs. In addition, ELK1 and SAP1a can also form quaternary complexes on the Egr1 SREI. Clinical significance
20807 Ensembl ENSG00000112658 ENSMUSG00000015605 UniProt P11831 Q9JM73 RefSeq (mRNA) NM_003131 NM_001292001 NM_020493 RefSeq (protein) NP_001278930 NP_003122 NP_003122.1 NP_065239 Location (UCSC) Chr 6: 43.17 – 43.18 Mb Chr 17: 46.86 – 46.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Serum response factor, also known as SRF, is a transcription factor protein. Function Serum ...
The canonical haemodynamic response function (HRF). The spike indicates a brief intense period of neuron stimulation, which requires increased blood and nutrient flow. As the needs of the neuronal activity are met, blood flow returns to homeostatic levels. In haemodynamics, the body must respond to physical activities, external temperature, and ...
An SRF technology single-cell Niobium cavity CAD image with cross section, as used in the KEK-B [1] accelerator. Superconducting radio frequency (SRF) science and technology involves the application of electrical superconductors to radio frequency devices. The ultra-low electrical resistivity of a superconducting material allows an RF resonator ...
In molecular biology, extracellular signal-regulated kinases ( ERKs) or classical MAP kinases are widely expressed protein kinase intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. Many different stimuli, including growth factors ...
In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placental mammals and marsupials). [5]
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene.