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Similarly, dysfunctional SRF, which normally tethers Elk1 to the SRE, leads to Fos not being transcribed. [21] At the same time, without Elk1, SRF cannot induce c-fos transcription after MAPK stimulation. [16] For these reasons, Elk1 represents an essential link between signal transduction pathways and the initiation of gene transcription.
ELK1 and SAP1a have been shown to form ternary complexes with SRF on the serum response elements (SRE) located in the c-fos promoter. ELK1, SAPla, FLI1 and EWS-FLI1 are able to form ternary complexes with SRF on EGR1 SREs. In addition, ELK1 and SAP1a can also form quaternary complexes on the Egr1 SREI. Clinical significance
An SRF technology single-cell Niobium cavity CAD image with cross section, as used in the KEK-B [1] accelerator. Superconducting radio frequency (SRF) science and technology involves the application of electrical superconductors to radio frequency devices. The ultra-low electrical resistivity of a superconducting material allows an RF resonator ...
The original video by Pinkfong is now the most viewed video on the site. On October 29, 2020, Baby Shark surpassed 7 billion views, and on November 2, 2020, it passed Despacito to become the most viewed video on YouTube. On February 23, 2021, Baby Shark surpassed 8 billion views, becoming the first video to do so.
Leila Register. Women who spend time on TikTok are at a greater risk of disliking their own bodies and feeling worse about their appearance — especially if they’ve been exposed to pro-anorexia ...
This was the first concert video to be aired on MTV, from REO Speedwagon's Live Infidelity home video release. The video was interrupted after 12 seconds due to technical difficulties. The technical difficulty moment contains only a blank black screen with a 200 Hz tone for a few seconds before going back to MTV's studio. 10 "Rockin' the Paradise"
August 6, 2024 at 5:56 PM. The surfing competition is making waves at the 2024 Summer Olympics. During the Aug. 5 women’s shortboard semifinal match between Brazil’s Tatiana Weston-Webb and ...
They've opted for workouts at home to help manage the stress of separation anxiety. This is a big sacrifice, which most parents can attest to, as working out with our pups is no simple task. They ...