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Diphenhydramine ( DPH) is an antihistamine and sedative mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly used for tremors in parkinsonism, and nausea. [ 11] It is taken by mouth, injected into a vein, injected into a muscle, or applied to the skin. [ 11]
As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor. As a first-generation antihistamine, it typically crosses the blood–brain barrier into the brain, thereby producing a suite of sedative and hypnotic effects that are mediated by the central nervous system. (N.b.:
H. 1. antagonist. H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic ...
Sominex is the trademarked name for several over the counter sleep aids. Different formulations of Sominex are available, depending upon the market. Both the US and UK formulations contain a significant dose of a first generation antihistamine with hypnotic properties. In the United States, Sominex is marketed by Prestige Brands, [ 1] sometimes ...
Benadryl Allergy. Benadryl Allergy is the name of a Benadryl product found in the United States and Canada. It is an antihistamine drug used to relieve allergies. Its active ingredient is diphenhydramine, a first-generation antihistamine. It is known to be sedative, making drowsiness a common side effect.
Dimenhydrinate. Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio.
Doxepin is a medication belonging to the tricyclic antidepressant (TCA) [ 10] class of drugs used to treat major depressive disorder, anxiety disorders, chronic hives, and insomnia. [ 10][ 11] For hives it is a less preferred alternative to antihistamines. [ 10] It has a mild to moderate benefit for sleeping problems. [ 12]
Bilastine is an antihistamine medication used to treat hives (), allergic rhinitis and itchy inflamed eyes (allergic conjunctivitis) caused by an allergy. [6] It is a second-generation antihistamine and takes effect by selectively inhibiting the histamine H 1 receptor, preventing these allergic reactions. [7]
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