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A prolonged-release 2 mg oral formulation of melatonin sold under the brand name Circadin is approved for use in the European Union in the short-term treatment of insomnia in people age 55 and older. [11] [29] [8] Melatonin is also available as an over-the-counter dietary supplement in many countries. It is available in both immediate-release ...
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Sedatives and hypnotics should be avoided in people with dementia, [24] according to the medication appropriateness tool for co‐morbid health conditions in dementia criteria. [25] The use of these medications can further impede cognitive function for people with dementia, who are also more sensitive to side effects of medications.
The Sleep Foundation states that herb has been shown to safely improve relaxation and sleep, but should always be used with caution and should not be used long term or with other sleep aids ...
Sleeping pills, including the Z-drugs, have been associated with an increased risk of death. [34] In older people this family of medications increases the risk of fractures and falls. [35] The Z-drug zaleplon may have fewer side effects compared to benzodiazepines. [36]
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