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Sildenafil and other PDE5 inhibitors are used off-label to alleviate vasospasm and treat severe ischemia and ulcers in fingers and toes for people with secondary Raynaud's phenomenon; [9] [21] these drugs have moderate efficacy for reducing the frequency and duration of vasospastic episodes. [9]
Escitalopram. Escitalopram, sold under the brand names Lexapro and Cipralex, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. [9] Escitalopram is mainly used to treat major depressive disorder and generalized anxiety disorder. [9] It is taken by mouth, [9] available commercially as an oxalate salt ...
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It is conjugated in the kidney for excretion in the urine, where 75% of the drug is excreted, [114] and about 15% is eliminated in feces. [115]: 430 Desmethylmirtazapine is an active metabolite of mirtazapine which is believed to contribute about 3-10% to the drugs overall effects and has a half-life of about 25 hours. [8]
In some countries, such as Brazil (photo) and France, more than 20% of all drug sales in units are generic. A generic drug (or simply generic) is a pharmaceutical drug that contains the same chemical substance as a drug that was originally protected by chemical patents. Generic drugs are allowed for sale after the patents on the original drugs ...
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U.S. Food and Drug Administration. 9 May 2017. "Warning use metformin in certain patients with reduced kidney function". U.S. Food and Drug Administration. 14 November 2017. "Warning: infection of genital area with SGLT2 inhibitors for diabetes". U.S. Food and Drug Administration. 7 September 2018.
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