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Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7][4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2] [6] At a dose of 15 to 20 mg and in terms of treatment–placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes, and increases total sleep time by about 10 to 20 minutes. [2]
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. [11] [16] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after behavioral changes, such as sleep hygiene, have been tried.
Eszopiclone, sold under the brand name Lunesta among others, is a medication used in the treatment of insomnia. [3][4] Evidence supports slight to moderate benefit up to six months. [5][4][6] It is taken by mouth. [3][5] Common side effects include headache, dry mouth, nausea, and dizziness. [5] Severe side effects may include suicidal thoughts ...
Dextroamphetamine is used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy (a sleep disorder), [11] and is sometimes prescribed off-label for depression and obesity. [ 28 ] Dextroamphetamine reduces the negative symptoms of schizophrenia , and has been shown to enhance the effects of auditory discrimination training in ...
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