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AST/ALT ratio. LOINC. 16325-3, 1916-6. The AST/ALT ratio or De Ritis ratio is the ratio between the concentrations of two enzymes, aspartate transaminase (AST) and alanine transaminase, aka alanine aminotransferase (ALT), in the blood of a human or animal. It is used as one of several liver function tests, and measured with a blood test.
Liver function tests. Liver function tests ( LFTs or LFs ), also referred to as a hepatic panel, are groups of blood tests that provide information about the state of a patient's liver. [ 1] These tests include prothrombin time (PT/INR), activated partial thromboplastin time (aPTT), albumin, bilirubin (direct and indirect), and others.
In medicine, the presence of elevated transaminases, commonly the transaminases alanine transaminase (ALT) and aspartate transaminase (AST), may be an indicator of liver dysfunction. [ 1][ 2] Other terms include transaminasemia, [ 3] and elevated liver enzymes (though they are not the only enzymes in the liver).
Aspartate transaminase ( AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic transaminase ( GOT, SGOT ), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme ( EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954. [ 1][ 2][ 3] AST catalyzes the reversible transfer of ...
AST levels typically are higher than ALT. This remains the case in most liver disorders except for hepatitis (viral or hepatotoxic). Alcoholic liver damage may have fairly normal ALT levels, with AST 10 times higher than ALT. If ALT is higher than AST, however, this is indicative of hepatitis. Levels of ALT and AST are not well correlated to ...
The transaminase enzymes are important in the production of various amino acids, and measuring the concentrations of various transaminases in the blood is important in the diagnosing and tracking many diseases. [citation needed] For example, the presence of elevated transaminases can be an indicator of liver and cardiac damage.
Gastroenterology. Alcoholic liver disease ( ALD), also called alcohol-related liver disease ( ARLD ), is a term that encompasses the liver manifestations of alcohol overconsumption, including fatty liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cirrhosis. [ 1]
Alanine transaminase ( ALT) is a transaminase enzyme ( EC 2.6.1.2 ). It is also called alanine aminotransferase ( ALT or ALAT) and was formerly called serum glutamate-pyruvate transaminase or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. [ 1]
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