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Fentanyl is a highly potent synthetic piperidine opioid primarily used as an analgesic. It is 20 to 40 times more potent than heroin and 100 times more potent than morphine; [ 9 ] its primary clinical utility is in pain management for cancer patients and those recovering from painful surgeries. [ 10 ][ 11 ] Fentanyl is also used as a sedative ...
Tramadol. Tramadol, sold under the brand name Ultram among others, [1] is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderately severe pain. [3][14] When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. [3]
Hydromorphone is a semi-synthetic μ-opioid agonist. As a hydrogenated ketone of morphine, it shares the pharmacologic properties typical of opioid analgesics. Hydromorphone and related opioids produce their major effects on the central nervous system and gastrointestinal tract.
Methoxyflurane, sold under the brand name Penthrox among others, is an inhaled medication primarily used to reduce pain following trauma. [ 5 ][ 6 ] It may also be used for short episodes of pain as a result of medical procedures. [ 4 ] Onset of pain relief is rapid and of a short duration. [ 4 ] Use is only recommended with direct medical ...
Metamizole. Urine (96%, IV; 85%, oral), faeces (4%, IV). [4] Metamizole or dipyrone is a painkiller, spasm reliever, and fever reliever drug. It is most commonly given by mouth or by intravenous infusion. [13][11][14] It belongs to the ampyrone sulfonate family of medicines and was patented in 1922.
Gastrointestinal side effects may include abdominal pain, constipation, diarrhea, and nausea. [ 5 ] [ 87 ] [ 101 ] Other potential physical side effects include appetite loss , blurred vision , dry mouth , excessive grinding of the teeth , nosebleed, profuse sweating, rhinitis medicamentosa (drug-induced nasal congestion), reduced seizure ...
A 2006 review found that controlled-release oxycodone is comparable to immediate-release oxycodone, morphine, and hydromorphone in management of moderate to severe cancer pain, with fewer side effects than morphine. The author concluded that the controlled-release form is a valid alternative to morphine and a first-line treatment for cancer ...
Methadone, sold under the brand names Dolophine and Methadose among others, is a synthetic opioid used medically to treat chronic pain and opioid use disorder. [ 7 ] Prescribed for daily use, the medicine relieves cravings and opioid withdrawal symptoms. [ 10 ]