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Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
Doxylamine succinate is the active ingredient in many over-the-counter sleep-aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Suvorexant is used for the treatment of insomnia, characterized by difficulties with sleep onset and/or sleep maintenance, in adults. [2] [6] At a dose of 15 to 20 mg and in terms of treatment–placebo difference, it reduces time to sleep onset by up to 10 minutes, reduces time awake after sleep onset by about 15 to 30 minutes, and increases total sleep time by about 10 to 20 minutes. [2]
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Trazodone. Trazodone, sold under many brand names, [ 1] is an antidepressant medication. [ 20] It is used to treat major depressive disorder, anxiety disorders, and insomnia. [ 20] The medication is taken orally. [ 20]
Hydroxyzine. Hydroxyzine, sold under the brand names Atarax and Vistaril among others, is an antihistamine medication. [ 8] It is used in the treatment of itchiness, insomnia, anxiety, and nausea, including that due to motion sickness. [ 8] It is used either by mouth or injection into a muscle. [ 8]
Daridorexant. Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. [ 1][ 4][ 6][ 7][ 8] Daridorexant is taken by mouth. [ 1][ 4][ 7] Side effects of daridorexant include headache, somnolence, and fatigue. [ 1][ 7] The medication is a dual orexin receptor antagonist ...
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