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Smallpox was an infectious disease caused by variola virus (often called smallpox virus), which belongs to the genus Orthopoxvirus. [7] [11] The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, [10] making smallpox the only human disease to have been eradicated to date.
The history of smallpox extends into pre-history. [ 1] Genetic evidence suggests that the smallpox virus emerged 3,000 to 4,000 years ago. [ 2] Prior to that, similar ancestral viruses circulated, but possibly only in other mammals, and possibly with different symptoms. Only a few written reports dating from about 500 AD to 1000 AD are ...
Collapse of population in Mexico during the 16th century, attributed to repeated epidemics of smallpox and cocoliztli. Mexico's native population was one of the first to experience a smallpox epidemic, where many succumbed to the disease. In 1520, the first wave of smallpox killed 5-8 million people. From 1545 to 1576, up to 17 million people ...
Edward Jenner FRS FRCPE [ 1] (17 May 1749 – 26 January 1823) was an English physician and scientist who pioneered the concept of vaccines and created the smallpox vaccine, the world's first vaccine. [ 2][ 3] The terms vaccine and vaccination are derived from Variolae vaccinae ('pustules of the cow'), the term devised by Jenner to denote cowpox.
1775–1782 North American smallpox epidemic. George Washington by Charles Willson Peale, 1776. The New World of the Western Hemisphere was devastated by the 1775–1782 North American smallpox epidemic. Estimates based on remnant settlements say at least 130,000 people were estimated to have died in the epidemic that started in 1775.
Clade 1 is more severe and can kill up to 10% of people infected. Clade 2 triggered the 2022 outbreak; more than 99% of people infected survived. ... However, antivirals for smallpox may be used ...
The FBI and the Center for Disease Control and Prevention are investigating “questionable vials” labeled "smallpox" and found in a freezer last night at a Merck facility outside Philadelphia.
Mpox ( / ˈɛmpɒks /, EM-poks; formerly known as monkeypox) [ 7] is an infectious viral disease that can occur in humans and other animals. [ 1] Symptoms include a rash that forms blisters and then crusts over, fever, and swollen lymph nodes. [ 1] The illness is usually mild, and most of infected individuals recover within a few weeks without ...