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It is thought to activate these receptors in the suprachiasmatic nucleus of the hypothalamus in the brain to regulate the circadian clock and sleep–wake cycles. [21] Immediate-release melatonin has a short elimination half-life of about 20 to 50 minutes. [22] [9] [10] Prolonged-release melatonin used as a medication has a half-life of 3.5 to ...
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Modafinil, sold under the brand name Provigil among others, is a wakefulness-promoting medication used primarily to treat narcolepsy, [3] [8] [12] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [13]
For many, getting a good night’s sleep has not been an easy feat during the pandemic. If you’re looking for an effective sleep, non-habit-forming sleep aid, elevating your nighttime routine ...
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