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Suvorexant, sold as Belsomra, is a medication for insomnia that acts by blocking orexin receptors in the brain. It helps with sleep onset and maintenance, but may cause side effects such as somnolence, headache, and abnormal dreams.
Loprazolam is a short-acting benzodiazepine medication that is used for the short-term treatment of moderately-severe insomnia. It has anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties, but also has side effects, risks of dependence and withdrawal, and interactions with other drugs.
Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist that treats insomnia by improving sleep onset and maintenance. It has a long elimination half-life, a low potential for misuse, and few interactions with other drugs.
Zopiclone is used to treat insomnia, but can cause dependence, withdrawal and cognitive impairment. It is a controlled substance in some countries and has side effects such as amnesia, paradoxical reactions and falls in the elderly.
Zaleplon, sold under the brand name Sonata among others, is a nonbenzodiazepine or Z-drug used to treat insomnia. It has a short half-life, few adverse effects, and may not affect driving performance, but it is not recommended for chronic use in the elderly or during pregnancy.
Estazolam is a benzodiazepine that acts on the GABA receptors in the brain to produce anxiolytic, anticonvulsant, hypnotic, sedative and muscle relaxant effects. It is used for short-term treatment of insomnia and anxiety, but has side effects, risks and interactions that require caution and monitoring.
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