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A common presentation of sleep apnea in children with autism is insomnia. [67] All known genetic syndromes which are linked to autism have a high prevalence of sleep apnea. The prevalence of sleep apnea in Down's Syndrome is 50% - 100%. [68] Sleep problems and OSA in this population have been linked to language development. [69]
Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
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