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Children appear to be at a high risk for cardiopulmonary arrest. A toxic dose for children of more than 1.8 mg/kg has been reported. A 3-year-old child died 18 hours after ingesting 1,000 mg doxylamine succinate. [5] Rarely, an overdose results in rhabdomyolysis and acute kidney injury. [36]
A subsequent 1990 study found that the elimination half-life of diphenhydramine was 5.4 hours in children, 9.2 hours in young adults, and 13.5 hours in the elderly. [7] A 1998 study found a half-life of 4.1 ± 0.3 hours in young men, 7.4 ± 3.0 hours in elderly men, 4.4 ± 0.3 hours in young women, and 4.9 ± 0.6 hours in elderly women. [85]
Non-24-hour sleep–wake disorder ( non-24[ 1] or N24SWD[ 2]) is one of several chronic circadian rhythm sleep disorders (CRSDs). It is defined as a "chronic steady pattern comprising [...] daily delays in sleep onset and wake times in an individual living in a society". [ 3] Symptoms result when the non-entrained ( free-running) endogenous ...
Children (1 to 2 years) need 11 to 14 hours, including naps. Children (3 to 5 years) need 10 to 13 hours, including naps ... If you're getting the recommended seven to nine hours of sleep a night ...
Ramelteon is approved for the treatment of insomnia characterized by difficulty with sleep onset in adults. [ 3][ 5] In regulatory clinical trials, it was found to significantly reduce latency to persistent sleep (LPS). [ 3] A 2009 pooled analysis of four clinical trials found that ramelteon at a dose of 8 mg reduced sleep onset by 13 minutes ...
Alprazolam, sold under the brand name Xanax and others, is a fast-acting, potent tranquilizer of moderate duration within the triazolobenzodiazepine group of chemicals called benzodiazepines. [15]
Flunitrazepam, sold under the brand name Rohypnol among others, [3] is a benzodiazepine used to treat severe insomnia and assist with anesthesia. [4] As with other hypnotics, flunitrazepam has been advised to be prescribed only for short-term use or by those with chronic insomnia on an occasional basis.
A dose of doxepin as low as 1 mg/day was found to significantly improve most of the assessed sleep measures, but unlike the 3 and 6 mg/day doses, was not able to improve wake time during sleep. [12] This, along with greater effect sizes with the higher doses, was likely the basis for the approval of the 3 and 6 mg doses of doxepin for insomnia ...
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