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Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
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The plasma maximum concentration of melatonin at night are 80–120 pg/mL and the concentrations during the day are between 10–20 pg/mL. [75] [76] Many animals and humans use the variation in duration of melatonin production each day as a seasonal clock. [77]
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Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. [10] [12] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after behavioral changes, such as sleep hygiene, have been tried.
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