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Drugs or medicines may be withdrawn from commercial markets because of risks to patients, but also because of commercial reasons (e.g. lack of demand and relatively high production costs). Where risks or harms is the reason for withdrawal, this will usually have been prompted by unexpected adverse effects that were not detected during Phase III clinical trials, i.e. they were only made ...
WHO Model List of Essential Medicines. The WHO Model List of Essential Medicines (aka Essential Medicines List or EML [1] ), published by the World Health Organization (WHO), contains the medications considered to be most effective and safe to meet the most important needs in a health system. [2] The list is frequently used by countries to help ...
Largest selling pharmaceutical products of 2015 Drugs with sales above $5 billion in 2015 included: [2] [3]
ACE inhibitors inhibit the activity of angiotensin-converting enzyme, an important component of the renin–angiotensin system which converts angiotensin I to angiotensin II, [3] and hydrolyses bradykinin. [1] Therefore, ACE inhibitors decrease the formation of angiotensin II, a vasoconstrictor, and increase the level of bradykinin, a peptide vasodilator. [1] [3] This combination is ...
Opioid antagonist. An opioid antagonist, or opioid receptor antagonist, is a receptor antagonist that acts on one or more of the opioid receptors . Fentanyl. 2 mg (white powder to the right) is a lethal dose in most people. [1] US penny is 19 mm (0.75 in) wide. Naloxone and naltrexone are commonly used opioid antagonist drugs which are ...
Drug Abuse Resistance Education, or D.A.R.E., is an American education program that tries to prevent use of controlled drugs, membership in gangs, and violent behavior. It was founded in Los Angeles in 1983 as a joint initiative of then- LAPD chief Daryl Gates and the Los Angeles Unified School District [1] [2] as a demand -side drug control strategy of the American War on Drugs .
Lipid-lowering agent. Lipid-lowering agents, also sometimes referred to as hypolipidemic agents, cholesterol-lowering drugs, or antihyperlipidemic agents are a diverse group of pharmaceuticals that are used to lower the level of lipids and lipoproteins, such as cholesterol, in the blood ( hyperlipidemia ).
Valsartan was patented in 1990, and came into medical use in 1996. [10] It is available as a generic medication. [11] In 2021, it was the 120th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [12] [13] Versions are available as the combinations valsartan/hydrochlorothiazide, [14] valsartan/amlodipine, [15] valsartan/amlodipine ...
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