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Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. [ 9 ] It has also been used in alcohol dependence and essential tremor. [ 9 ] For epilepsy this includes treatment for generalized or focal seizures. [ 10 ] It is taken orally (by mouth).
Maintenance therapy with antipsychotic drugs is clearly superior to placebo in preventing relapse but is associated with weight gain, movement disorders, and high dropout rates. [38] A 3-year trial following persons receiving maintenance therapy after an acute psychotic episode found that 33% obtained long-lasting symptom reduction, 13% ...
Produces roughly as much weight gain as risperidone, less weight gain than clozapine, olanzapine and zotepine and more weight gain than ziprasidone, lurasidone, aripiprazole and asenapine. [20] As with many other atypical antipsychotics, this action is likely due to its actions at the H 1 histamine receptor and 5-HT 2C receptor .
Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease. [11] [13] [14] The most common side effects include akathisia (a constant urge to move) and weight gain. [12]
Although antagonistic effects of olanzapine at 5-HT 2C alone is not associated with weight gain, olanzapine antagonism at histaminergic H 1, and muscarinic M 3 receptors have been implicated in weight gain. [70] [100] [101] The mode of action of olanzapine's antipsychotic activity is unknown. It may involve antagonism of dopamine and serotonin ...
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects. [26] With more than 6 months of use 14 percent of users gain weight. [38] Haloperidol may be neurotoxic. [39] Common (>1% incidence) Extrapyramidal side effects including:
Thioridazine ( Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in ...