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The use of antipsychotics may result in many unwanted side effects such as involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce adverse effects such as tardive dyskinesia, tardive dystonia, and tardive akathisia.
According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects. [26] With more than 6 months of use 14 percent of users gain weight. [38] Haloperidol may be neurotoxic. [39] Common (>1% incidence) Extrapyramidal side effects including:
Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease. [11] [13] [14] The most common side effects include akathisia (a constant urge to move) and weight gain. [12]
Clozapine is a psychiatric medication and was the first atypical antipsychotic (also called second-generation antipsychotic) to be discovered. [6] It is primarily used to treat people with schizophrenia and schizoaffective disorder who have had an inadequate response to two other antipsychotics, or who have been unable to tolerate other drugs due to extrapyramidal side effects.
A 2013 systematic review compared pimozide with other antipsychotics for schizophrenia or related psychoses: Pimozide versus any other antipsychotic [4]. In one case a series of 33 patients with delusional parasitosis (median age, 60 years), pimozide was prescribed for 24 patients, 18 of whom took the drug.
Cyproheptadine is sometimes used off-label to improve akathisia in people on antipsychotic medications. [ 12 ] It is used off-label to treat various dermatological conditions, including psychogenic itch , [ 13 ] drug-induced hyperhidrosis (excessive sweating), [ 14 ] and prevention of blister formation for some people with epidermolysis bullosa ...
Asenapine. Asenapine, sold under the brand name Saphris among others, is an atypical antipsychotic medication used to treat schizophrenia and acute mania associated with bipolar disorder as well as the medium to long-term management of bipolar disorder. [ 4][ 10]
Typical antipsychotic. Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia ). Typical antipsychotics may also be used for the treatment of acute mania, agitation, and other conditions.