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Discovery and development of bisphosphonates. Chemical structure of bisphosphonates. Bisphosphonates are an important class of drugs originally commercialised in the mid to late 20th century. They are used for the treatment of osteoporosis and other bone disorders that cause bone fragility and diseases where bone resorption is excessive.
Bisphosphonates are used to treat osteoporosis, osteitis deformans (Paget's disease of the bone), bone metastasis (with or without hypercalcemia), multiple myeloma, and other conditions involving fragile, breakable bone. In osteoporosis and Paget's, the most popular first-line bisphosphonate drugs are alendronate and risedronate.
Alendronic acid. Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. [3] It is taken by mouth. [3] Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes. [3]
Bisphosphonates are popular drugs for treatment of osteoporosis. Clodronic acid is a bisphosphonate used as a drug to treat osteoporosis. In biochemistry and medicinal chemistry, phosphonate groups are used as stable bioisosteres for phosphate, such as in the antiviral nucleotide analog, Tenofovir, one of the cornerstones of anti-HIV therapy.
Phossy jaw. Phossy jaw, formally known as phosphorus necrosis of the jaw, was an occupational disease affecting those who worked with white phosphorus (also known as yellow phosphorus) without proper safeguards. It is also likely to occur as the result of use of chemical weapons that contain white phosphorus.
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Frequency. 15% (50 year olds), 70% (over 80 year olds) [7] Osteoporosis is a systemic skeletal disorder characterized by low bone mass, micro-architectural deterioration of bone tissue leading to more porous bone, and consequent increase in fracture risk. It is the most common reason for a broken bone among the elderly. [3]
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