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As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor. As a first-generation antihistamine, it typically crosses the blood–brain barrier into the brain, thereby producing a suite of sedative and hypnotic effects that are mediated by the central nervous system. (N.b.:
Methaqualone is a hypnotic sedative. It was sold under the brand names Quaalude ( / ˈkweɪluːd / KWAY-lood) and Sopor among others, which contained 300 mg of methaqualone, and sold as a combination drug under the brand name Mandrax, which contained 250 mg methaqualone and 25 mg diphenhydramine within the same tablet, mostly in Europe.
Used for severe insomnia. Hypnotic (from Greek Hypnos, sleep [ 1] ), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep [ 2] (or surgical anesthesia [ note 1]) and to treat insomnia (sleeplessness). This group of drugs is related to sedatives.
The CDC report, released to coincide with International Overdose Awareness Day, found that from mid-2019 to the end of 2021, overdose deaths involving counterfeit drugs more than doubled, from 2% ...
Eszopiclone is classified as a nonbenzodiazepine or Z-drug and a sedative and hypnotic of the cyclopyrrolone group. [ 7] It is the S- stereoisomer of zopiclone. [ 5][ 8] It works by interacting with the GABA receptors. [ 7] Approved for medical use in the United States in 2004, [ 3] eszopiclone is available as a generic medication. [ 5]
Etizolam pills. Etizolam, a thienodiazepine derivative, is absorbed fairly rapidly, with peak plasma levels achieved between 30 minutes and 2 hours. It has a mean elimination half life of about 3.4 hours. [ 4][ 2][ 3] Etizolam possesses potent hypnotic properties, [ 23] and is comparable with other short-acting benzodiazepines. [ 4]
Overdose deaths reached record levels in the United States in recent years, and a new report shows that counterfeit pills are involved in a growing share of those deaths.
Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine, specifically cyclopyrrolones, used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone. However, zopiclone increases the normal transmission of the neurotransmitter gamma-aminobutyric acid ...
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