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Alpidem (Ananxyl) 1995. Worldwide. Not approved in the US, withdrawn in France in 1994 [4] and the rest of the market in 1995 because of rare but serious hepatotoxicity. [3] [5] Alosetron (Lotronex) 2000. US. Serious gastrointestinal adverse events; ischemic colitis; severe constipation. [2]
Off-label use. Off-label use is the use of pharmaceutical drugs for an unapproved indication or in an unapproved age group, dosage, or route of administration. [1] Both prescription drugs and over-the-counter drugs (OTCs) can be used in off-label ways, although most studies of off-label use focus on prescription drugs.
MDMA is a moderately teratogenic drug (i.e., it is toxic to the fetus). [101] [102] In utero exposure to MDMA is associated with a neuro - and cardiotoxicity [102] and impaired motor functioning. Motor delays may be temporary during infancy or long-term.
In pharmacology, a drug is a chemical substance, typically of known structure, which, when administered to a living organism, produces a biological effect. [3] A pharmaceutical drug, also called a medication or medicine, is a chemical substance used to treat, cure, prevent, or diagnose a disease or to promote well-being. [1]
Drug policy. A drug policy is the policy regarding the control and regulation of psychoactive substances (commonly referred to as drugs), particularly those that are addictive or cause physical and mental dependence. While drug policies are generally implemented by governments, entities at all levels (from international organisations, national ...
Drug rehabilitation. The 2010 ISCD study "Drug Harms in the UK: a multi-criteria decision analysis " found that alcohol scored highest overall and in Economic cost, Injury, Family adversities, Environmental damage, and Community harm. Drug rehabilitation is the process of medical or psychotherapeutic treatment for dependency on psychoactive ...
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