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Target hardening, also referred to simply as hardening when made clear by the context, is a term used by police officers, those working in security, and the military referring to the strengthening of the security of a building or installation in order to protect it in the event of attack or reduce the risk of theft. [ 1][ 2] It is believed that ...
n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a n/a Wikidata View/Edit Human Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by the NP gene. It catalyzes the chemical reaction purine nucleoside + phosphate ⇌ {\displaystyle \rightleftharpoons ...
The disorder is caused by a mutation of the purine nucleoside phosphorylase (PNP) gene, located at chromosome 14q13.1. [ 3][ 4] This mutation was first identified by Eloise Giblett, a professor at the University of Washington, in 1975. [ 5] PNP is a key enzyme in the purine catabolic [ 6] pathway, and is required for purine degradation.
Specialty. Dermatology. Paraneoplastic pemphigus ( PNP) is an autoimmune disorder stemming from an underlying tumor. It is hypothesized that antigens associated with the tumor trigger an immune response resulting in blistering of the skin and mucous membranes . While patients with malignant and benign tumors are both at risk, malignancy is ...
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside the cell. [1] [2] [note 1] Proteins can be targeted to the inner space of an organelle, different intracellular membranes, the plasma membrane, or to the exterior of the cell via secretion.
Precipitation hardening, also called age hardening or particle hardening, is a heat treatment technique used to increase the yield strength of malleable materials, including most structural alloys of aluminium, magnesium, nickel, titanium, and some steels, stainless steels, and duplex stainless steel. In superalloys, it is known to cause yield ...
Strengthening mechanisms of materials. Methods have been devised to modify the yield strength, ductility, and toughness of both crystalline and amorphous materials. These strengthening mechanisms give engineers the ability to tailor the mechanical properties of materials to suit a variety of different applications.
Work hardening, also known as strain hardening, is the process by which a material's load-bearing capacity (strength) increases during plastic (permanent) deformation. This characteristic is what sets ductile materials apart from brittle materials. [ 1] Work hardening may be desirable, undesirable, or inconsequential, depending on the application.