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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Unfortunately, more than 60 million Americans suffer from poor sleep and over one third of Americans don’t get at least the recommended seven to nine hours of sleep each night.
Flurazepam is a long-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep, though benzodiazepines with intermediate half-lives such as loprazolam, lormetazepam, and temazepam are also indicated for patients with difficulty maintaining sleep. Flurazepam was temporarily unavailable in the United States ...
Surveys show that 40 to 70 percent of those 65 years old and older suffer from chronic sleep disturbances. The elderly tend to go to bed early in the evening and wake earlier in the morning than younger adults. Furthermore, the elderly often wake several times throughout the night and have difficulty falling asleep.
Many sleep aids assist in falling asleep faster, reducing the time it takes to transition into sleep and promoting a more efficient sleep onset. The Rise Of Quality Sleep Aids In 2023
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