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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Sleep disorders. Surveys show that 40 to 70 percent of those 65 years old and older suffer from chronic sleep disturbances. The elderly tend to go to bed early in the evening and wake earlier in the morning than younger adults. Furthermore, the elderly often wake several times throughout the night and have difficulty falling asleep.
Unfortunately, more than 60 million Americans suffer from poor sleep and over one third of Americans don’t get at least the recommended seven to nine hours of sleep each night.
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Sleep medicine is a medical specialty or subspecialty devoted to the diagnosis and therapy of sleep disturbances and disorders. [1] From the middle of the 20th century, research has provided increasing knowledge of, and answered many questions about, sleep–wake functioning. [2] The rapidly evolving field [3] has become a recognized medical ...
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