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CBD is hydroxylated by P450 liver enzymes into 7-OH-CBD. Its metabolites are products of primarily CYP2C19 and CYP3A4 activity, with potential activity of CYP1A1, CYP1A2, CYP2C9, and CYP2D6. [69] Similar to delta-9-THC, a majority of CBD is excreted in feces and some in the urine. [57] The terminal half-life is approximately 18–32 hours. [70]
Cannabidiol ( CBD) is a phytocannabinoid discovered in 1940. It is one of 113 identified cannabinoids in cannabis plants, along with tetrahydrocannabinol (THC), and accounts for up to 40% of the plant's extract. [ 17]
In the United States, the use of cannabis for medical purposes is legal in 38 states, four out of five permanently inhabited U.S. territories, and the District of Columbia, as of March 2023. [1] Ten other states have more restrictive laws limiting THC content, for the purpose of allowing access to products that are rich in cannabidiol (CBD), a ...
More than 800 Walmart stores across five states will now carry CBD products on their shelves. Charlotte’s Web, one of the biggest names in cannabidiol (CBD) and other hemp-derived botanical ...
One of the United States’ largest alcohol distributors, Southern Glazer's Wine & Spirits, has teamed up with Kill Cliff for a deal that will bring CBD beverages to retail stores in 46 states.
This is a list of the world's largest cannabis companies by revenue.The list shows cannabis companies ranked by annual revenue. The list includes companies whose primary business activities are associated with cannabis.
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Christianbook, LLC. Christianbook, LLC, formerly known as Christian Book Distributors ( CBD ), is a Christian catalog and internet retailer. Christian Book Distributors was started in 1978 by Stephen Hendrickson, 19 years old and a sophomore at Central Bible College in Springfield, Missouri, out of his parents’ home in Lynn, Massachusetts.