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By inhibiting 5α-reductase and thus preventing DHT production, finasteride reduces androgen signaling in tissues like the prostate gland and the scalp. In the prostate, this reduces prostate volume, which improves BPH and reduces risk of prostate cancer. Finasteride reduces prostate volume by 20 to 30% in men with benign prostatic hyperplasia ...
They have also been explored in the treatment and prevention of prostate cancer. While the 5-ARI finasteride reduces the cancer risk by about a third, it also increases the fraction of aggressive forms of prostate cancer. Overall, there does not seem to be a survival benefit for prostate cancer patients under finasteride. [5]
Finasteride and Prostate Cancer Risks Although finasteride is associated with a reduced overall risk of prostate cancer, some scientific research from 1993 suggests that it may contribute to an ...
5α-Reductase inhibitor drugs are used in benign prostatic hyperplasia, prostate cancer, pattern hair loss (androgenetic alopecia), and hormone replacement therapy for transgender women. Inhibition of the enzyme can be classified into two categories: steroidal, which are irreversible, and nonsteroidal.
Finasteride (commonly sold under the brand name Propecia or Proscar) is a 5 alpha-reductase inhibitor. ... In men over 55 years old, the risk of developing high-grade prostate cancer increases ...
Finasteride—which is also approved to treat enlarged prostate symptoms under the name Proscar—can be used alone or in combination with other hair loss treatments, like platelet-rich plasma ...
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