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Clonazepam is not recommended for use in those under 18. Use in very young children may be especially hazardous. Of anticonvulsant drugs, behavioural disturbances occur most frequently with clonazepam and phenobarbital. [92] [94] Doses higher than 0.5–1 mg per day are associated with significant sedation. [95]
It is available as a generic medication and marketed under many brand names worldwide. [1] [3] In 2021, it was the 41st most commonly prescribed medication in the United States, with more than 15 million prescriptions. [19] [20]
Pfizer originally discovered the medication in 1989 while looking for a treatment for angina. [11] It was approved for medical use in the United States and in the European Union in 1998. [5] [8] [11] [12] In 2021, it was the 157th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Lumateperone, sold under the brand name Caplyta, is an atypical antipsychotic medication of the butyrophenone class. It is approved for the treatment of schizophrenia as well as bipolar depression, as either monotherapy or adjunctive therapy (with lithium or valproate). [2]
Maropitant (INN; [2] brand name: Cerenia, used as maropitant citrate , is a neurokinin-1 (NK 1) receptor antagonist developed by Zoetis specifically for the treatment of motion sickness and vomiting in dogs. It was approved by the FDA in 2007, for use in dogs [3] [4] and in 2012, for cats. [5]
This drug is only used in cases with severe respiratory depression or cardiovascular complications. Because flumazenil is a short-acting drug, and the effects of diazepam can last for days, several doses of flumazenil may be necessary. Artificial respiration and stabilization of cardiovascular functions may also be necessary.