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Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
Quazepam. Quazepam, sold under the brand name Doral among others, is a relatively long-acting benzodiazepine derivative drug developed by the Schering Corporation in the 1970s. [ 2] Quazepam is used for the treatment of insomnia, including sleep induction and sleep maintenance. [ 3] Quazepam induces impairment of motor function and has ...
Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7] [4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Common side effects include sleepiness, headache, and a dry mouth. [8] [9] Serious side effects may include QT prolongation. [9] It is unclear if use during pregnancy or breastfeeding is safe. [8] Hydroxyzine works by blocking the effects of histamine. [9] It is a first-generation antihistamine in the piperazine family of chemicals. [8] [4]
Zolpidem is a nonbenzodiazepine or Z-drug which acts as a sedative and hypnotic. [ 10][ 16] Zolpidem is a GABA A receptor agonist of the imidazopyridine class. [ 10] It works by increasing GABA effects in the central nervous system by binding to GABA A receptors at the same location as benzodiazepines. [ 10]
Zopiclone, sold under the brand name Imovane among others, is a nonbenzodiazepine, specifically cyclopyrrolones, used to treat difficulty sleeping. Zopiclone is molecularly distinct from benzodiazepine drugs and is classed as a cyclopyrrolone. However, zopiclone increases the normal transmission of the neurotransmitter gamma-aminobutyric acid ...
Temazepam, similar to other benzodiazepines and nonbenzodiazepine hypnotic drugs, causes impairments in body balance and standing steadiness in individuals who wake up at night or the next morning. Falls and hip fractures are frequently reported. The combination with alcohol increases these impairments.
Daridorexant. Daridorexant, sold under the brand name Quviviq, is an orexin antagonist medication which is used for the treatment of insomnia. [ 1][ 4][ 6][ 7][ 8] Daridorexant is taken by mouth. [ 1][ 4][ 7] Side effects of daridorexant include headache, somnolence, and fatigue. [ 1][ 7] The medication is a dual orexin receptor antagonist ...
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