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Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed to its action on AMPK, although other mechanisms have been proposed. [209] [210] Metformin has been studied for its effects on multiple other conditions, including: Non-alcoholic fatty liver disease [211] [212] [213]
Vildagliptin/metformin is indicated in the treatment of type-2 diabetes mellitus: it is indicated in the treatment of adults who are unable to achieve sufficient glycaemic control at their maximally tolerated dose of oral metformin alone or who are already treated with the combination of vildagliptin and metformin as separate tablets.
Vildagliptin, sold under the brand name Galvus and others, is an oral anti-hyperglycemic agent ( anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 [ 2][ 3] and GIP [ 3] by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and ...
Metformin's prescribing information indicates diarrhea as a common side effect. Up to 53% who take metformin will have diarrhea. Up to 46% of people who take metformin will stop taking the ...
Diabetes medication. Drugs used in diabetes treat diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin, most GLP-1 receptor agonists ( liraglutide, exenatide, and others), and pramlintide, all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic ...
Side effects of metformin are typically mild and include GI (gastrointestinal) issues like gas, diarrhea or bloating. However, the FDA warns against using metformin if you have kidney disease or a ...
In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...
Adverse effects See also: Canagliflozin § Adverse_effects , and Metformin § Adverse_effects To lessen the risk of developing ketoacidosis (a serious condition in which the body produces high levels of blood acids called ketones) after surgery, the FDA approved changes to the prescribing information for SGLT2 inhibitor diabetes medicines to ...
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