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In 2005, the FDA issued an advisory warning of an increased risk of death when atypical antipsychotics are used in dementia. [47] In the subsequent 5 years, the use of atypical antipsychotics to treat dementia decreased by nearly 50%. [47] As of now, the only FDA-approved atypical antipsychotic for alzheimer-related dementia is brexpiprazole.
Medical condition Dementia with Lewy bodies Other names Diffuse Lewy body disease, dementia due to Lewy body disease Microscopic image of a Lewy body (arrowhead) in a neuron of the substantia nigra ; scale bar=20 microns (0.02 mm) Specialty Neurology, psychiatry Symptoms Dementia, abnormal behavior during REM sleep, fluctuations in alertness, visual hallucinations, parkinsonism Usual onset ...
Weight gain is an important adverse effect. [7] [33] Some authors recommend limiting the use of risperidone and aripiprazole to those with the most challenging behavioral disturbances in order to minimize the risk of drug-induced adverse effects. [34] Evidence for the efficacy of risperidone in autistic adolescents and young adults is less ...
Maintenance therapy with antipsychotic drugs is clearly superior to placebo in preventing relapse but is associated with weight gain, movement disorders, and high dropout rates. [38] A 3-year trial following persons receiving maintenance therapy after an acute psychotic episode found that 33% obtained long-lasting symptom reduction, 13% ...
Story at a glance Prescriptions of antipsychotic drugs increased for people with dementia substantially in the initial months of the pandemic and remained elevated in 2021, according to a study ...
Atypical antipsychotics remain the first-line treatment for psychosis associated with various psychiatric and neurological disorders including schizophrenia, bipolar disorder, major depressive disorder, anxiety disorders, dementia, and some autism spectrum disorders. [153]
Similarly, lurasidone should not be used to treat dementia-related psychosis, as evidence has shown increased mortality with antipsychotic use. [57] Weight gain is reported in up to 15 and 16 percent of users. [58] [59] Other possible side effects include vomiting, akathisia, dystonia, parkinsonism, somnolence, dizziness, sedation and nausea ...
The DSM and the ICD characterize bipolar disorder as a spectrum of disorders occurring on a continuum. The DSM-5 and ICD-11 lists three specific subtypes: [ 5 ] [ 95 ] Bipolar I disorder : At least one manic episode is necessary to make the diagnosis; [ 109 ] depressive episodes are common in the vast majority of cases with bipolar disorder I ...