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Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic medication used for the treatment of major depressive disorder, schizophrenia, and agitation associated with dementia due to Alzheimer's disease. [11] [13] [14] The most common side effects include akathisia (a constant urge to move) and weight gain. [12]
The use of antipsychotics may result in many unwanted side effects such as involuntary movement disorders, gynecomastia, impotence, weight gain and metabolic syndrome. Long-term use can produce adverse effects such as tardive dyskinesia, tardive dystonia, and tardive akathisia.
In 2005, the FDA issued an advisory warning of an increased risk of death when atypical antipsychotics are used in dementia. [47] In the subsequent 5 years, the use of atypical antipsychotics to treat dementia decreased by nearly 50%. [47] As of now, the only FDA-approved atypical antipsychotic for alzheimer-related dementia is brexpiprazole.
According to a 2013 meta-analysis of the comparative efficacy and tolerability of 15 antipsychotic drugs it was the most prone of the 15 for causing extrapyramidal side effects. [26] With more than 6 months of use 14 percent of users gain weight. [38] Haloperidol may be neurotoxic. [39] Common (>1% incidence) Extrapyramidal side effects including:
Story at a glance Prescriptions of antipsychotic drugs increased for people with dementia substantially in the initial months of the pandemic and remained elevated in 2021, according to a study ...
Thioridazine ( Mellaril or Melleril) is a first generation antipsychotic drug belonging to the phenothiazine drug group and was previously widely used in the treatment of schizophrenia and psychosis. The branded product was withdrawn worldwide in 2005 because it caused severe cardiac arrhythmias. However, generic versions are still available in ...
Risperidone. Risperidone, sold under the brand name Risperdal among others, is an atypical antipsychotic [ 2] used to treat schizophrenia and bipolar disorder. [ 2] It is taken either by mouth or by injection (subcutaneous or intramuscular). [ 2] The injectable versions are long-acting and last for 2–4 weeks.
Dementia with Lewy bodies (DLB) is a type of dementia, a group of diseases involving progressive neurodegeneration of the central nervous system. [ 11] It is one of the two Lewy body dementias, along with Parkinson's disease dementia. [ 12] Dementia with Lewy bodies can be classified in other ways.