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[43] [44] Prolonged-release melatonin is safe with long-term use of up to 12 months. [11] Although not recommended for long-term use beyond this, [45] low-dose melatonin is generally safer, and a better alternative, than many prescription and over-the-counter sleep aids if a sleeping medication must be used for an extended period of time.
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [ 1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.
Zaleplon. Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [ 6] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
Fact: a terrible night’s sleep (or an all nighter) can leave you feeling awful the next day. Unfortunately, more than 60 million Americans suffer from poor sleep and over one third of Americans ...
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Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping. [ 1][ 11] They may have difficulty falling asleep, or staying asleep for as long as desired. [ 1][ 9][ 12] Insomnia is typically followed by daytime sleepiness, low energy, irritability, and a depressed mood. [ 1] It may result in an increased risk of ...
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