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Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7][4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Doxepin is a medication belonging to the tricyclic antidepressant (TCA) [10] class of drugs used to treat major depressive disorder, anxiety disorders, chronic hives, and insomnia. [10][11] For hives it is a less preferred alternative to antihistamines. [10] It has a mild to moderate benefit for sleeping problems. [12]
Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or delirium.
Flurazepam[2] (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. It produces a metabolite with a long half-life, which may stay in the bloodstream for days. [3]
In medical literature from Australia, Ireland, the UK, Canada, and the United States, temazepam is the only benzodiazepine which has been fatal in overdoses without combination with other CNS depresssants. This unique feature is due to the toxicity of the drug, which numerous studies have ranked it as being most toxic.
Siriano, 38, and Unisom (the sleep aid medication) have joined forces to expand upon the Met Gala’s “Sleeping Beauties: Reawakening Fashion” theme with an experience in New York City that ...
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