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Tissue-type plasminogen activator. Tissue-type plasminogen activator, short name tPA, is a protein that facilitates the breakdown of blood clots. It acts as an enzyme to convert plasminogen into its active form plasmin, the major enzyme responsible for clot breakdown. It is a serine protease ( EC 3.4.21.68) found on endothelial cells lining the ...
Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human tissue-type plasminogen activator (t-PA). It is a thrombolytic medication used to treat acute ischemic stroke, acute ST-elevation myocardial infarction (a type of heart attack), pulmonary embolism associated with low blood pressure, and blocked central venous catheter. [5]
Plasminogen activators are serine proteases that catalyze the activation of plasmin via proteolytic cleavage of its zymogen form plasminogen. Plasmin is an important factor in fibrinolysis, the breakdown of fibrin polymers formed during blood clotting. There are two main plasminogen activators: urokinase (uPA) and tissue plasminogen activator ...
Tenecteplase. Tenecteplase, sold under the trade names TNKase, Metalyse and Elaxim, is an enzyme used as a thrombolytic drug . Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line ( Chinese hamster ovary cells ). Tenecteplase is a 527 amino acid glycoprotein ...
View/Edit Human. View/Edit Mouse. Plasminogen activator inhibitor-1 ( PAI-1) also known as endothelial plasminogen activator inhibitor ( serpin E1) is a protein that in humans is encoded by the SERPINE1 gene. Elevated PAI-1 is a risk factor for thrombosis and atherosclerosis. [ 5]
Glossary of Medical Terms - Tufts University. Medical Abbreviations EN English Medical Abbreviations for Android. JD.MD, Inc. online Medical & Dental Abbreviations Glossary. Acronyms for Medical & Dental professional organizations. Medical Abbreviations for iPhone. Medical abbreviations on mediLexicon.
Thrombotic thrombocytopenic purpura ( TTP) is a blood disorder that results in blood clots forming in small blood vessels throughout the body. [ 2] This results in a low platelet count, low red blood cells due to their breakdown, and often kidney, heart, and brain dysfunction. [ 1] Symptoms may include large bruises, fever, weakness, shortness ...
ambiguous meaning, write out "days" or "doses". D5LR. dextrose 5% in lactated Ringer's solution ( intravenous sugar solution ) D5NS. dextrose 5% in normal saline (0.9%) ( intravenous sugar solution ) D5W, D 5 W. dextrose 5% in water ( intravenous sugar solution ) D10W, D 10 W. dextrose 10% in water ( intravenous sugar solution )