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Chemistry. [edit] Melatonin, also known as N -acetyl-5-methoxytryptamine, is a substituted tryptamine and a derivative of serotonin (5-hydroxytryptamine). It is structurally related to N-acetylserotonin (normelatonin; N -acetyl-5-hydroxytryptamine), which is the chemical intermediate between serotonin and melatonin in the body.
Insomnia, also known as sleeplessness, is a sleep disorder where people have trouble sleeping. [ 1 ][ 11 ] They may have difficulty falling asleep, or staying asleep for as long as desired. [ 1 ][ 9 ][ 12 ] Insomnia is typically followed by daytime sleepiness, low energy, irritability, and a depressed mood. [ 1 ]
Zolpidem, sold under the brand name Ambien among others, is a medication primarily used for the short-term treatment of sleeping problems. [11] [16] Guidelines recommend that it be used only after cognitive behavioral therapy for insomnia and after behavioral changes, such as sleep hygiene, have been tried.
In sleep medicine, we use very small doses of melatonin multiple hours before bed to help gradually shift the body’s clock (circadian rhythm) in people with delayed sleep phase disorder, jet lag ...
Zaleplon, sold under the brand name Sonata among others, is a sedative and hypnotic which is used to treat insomnia. It is a nonbenzodiazepine or Z-drug of the pyrazolopyrimidine class. [10] It was developed by King Pharmaceuticals and approved for medical use in the United States in 1999.
Eszopiclone, sold under the brand name Lunesta among others, is a medication used in the treatment of insomnia. [3][4] Evidence supports slight to moderate benefit up to six months. [5][4][6] It is taken by mouth. [3][5] Common side effects include headache, dry mouth, nausea, and dizziness. [5] Severe side effects may include suicidal thoughts ...
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