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Relaxin is a protein hormone of about 6000 Da, [1] first described in 1926 by Frederick Hisaw. [2] [3]The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Somnifacient (from Latin somnus, sleep [1] ), also known as sedatives or sleeping pills, is a class of medications that induces sleep. It is mainly used for treatment of insomnia. Examples of somnifacients include benzodiazepines, barbiturates and antihistamines . Around 2-6% of adults with insomnia use somnifacients to aid sleep. [2]
Modafinil, sold under the brand name Provigil among others, is a wakefulness-promoting medication used primarily to treat narcolepsy, [3] [8] [12] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [13] Modafinil is also approved for stimulating wakefulness in people with sleep apnea and shift work sleep ...
In sleep medicine, we use very small doses of melatonin multiple hours before bed to help gradually shift the body’s clock (circadian rhythm) in people with delayed sleep phase disorder, jet lag ...
Ramelteon is approved for the treatment of insomnia characterized by difficulty with sleep onset in adults. [ 3][ 5] In regulatory clinical trials, it was found to significantly reduce latency to persistent sleep (LPS). [ 3] A 2009 pooled analysis of four clinical trials found that ramelteon at a dose of 8 mg reduced sleep onset by 13 minutes ...
The recommendation for magnesium glycinate for sleep is 200 milligrams 30 minutes before going to sleep. Otherwise, magnesium supplements can be taken at any time of the day, with or without food ...
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